POSSIBLE MECHANISMS OF THE DEVELOPMENT OF INSULIN RESISTANCE IN OBESITY

Authors

  • Antonina Piddubna BGMU https://orcid.org/0000-0002-9143-9574
  • Ludmyla Honcharuk BGMU
  • Margarita Andrushchak BGMU
  • Vitalina Koba BGMU
  • Ivan Lysak BGMU
  • Kristina Makoviichuk BGMU

DOI:

https://doi.org/10.30888/2663-5712.2023-17-01-003

Keywords:

metabolic syndrome, obesity, body mass index, pathogenetic features, leptin, insulin resistance.

Abstract

Metabolic syndrome was previously associated with an increased risk of cardiovascular disease. However, research in recent decades has shown that the components of the metabolic syndrome have an effect on other systems of substances. The article provides

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References

MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16(3):293-311.

Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19(3):221-31.

Morrison CD, Brannigan RE. Metabolic syndrome and infertility in men. Best Pract Res Clin Obstet Gynaecol. 2015;29(4):507-15.

Bremer AA, Devaraj S, Afify A, Jialal I. Adipose Tissue Dysregulation in Patients with Metabolic Syndrome. J Clin Endocrinol Metab. 2011;96(11):E1782-8.

Craig JR, Jenkins TG, Carrell DT, Hotaling JM. Obesity, male infertility, and the sperm epigenome. Fertil Steril. 2017;107(4):848-59.

Lee M-J, Fried SK. Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. Am J Physiol Metab.2019;296(6):E1230-8.

Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2013;112(12):1796-808.

Sutherland JP, McKinley B, Eckel RH. The Metabolic Syndrome and Inflammation. Metab Syndr Relat Disord. 2014;2(2):82-104.

Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Influence of Metabolic Syndrome on Biomarkers of Oxidative Stress and Inflammation in Obese Adults. Obesity.2016;14(12):2127-31.

Published

2023-01-30

How to Cite

Поддубная, А., Гончарук, Л., Андрущак, М., Коба, В., Лысак, И., & Маковийчук, К. (2023). POSSIBLE MECHANISMS OF THE DEVELOPMENT OF INSULIN RESISTANCE IN OBESITY. SWorldJournal, 1(17-01), 26–30. https://doi.org/10.30888/2663-5712.2023-17-01-003

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