… , at least in part, from impaired insulin-dependent PI3K activation and downstream signaling.
… muscle insulin resistance in obesity and type 2 diabetes. In addition, the effects of insulin-…

… insulin action, thereby maintaining normal glucose tolerance 5,6,7 . For obesity and insulin
resistance … insulin sensitivity 8 . β-cell dysfunction exists in individuals who are at high risk of …

… If, as a result of insulin-resistance, the … in insulin sensitivity observed in obese hyperglycemic
patients after short-term fasting (4), which depletes the glycogen stores. The mechanisms …

… the development of insulin resistance and T2DM. Our results suggest that miRs may be
potential … environment associated with maternal obesity specifically during the periconceptional …

… pathways controlling insulin action. This review aims at providing an overview of these
concepts and their potential inter-relationships in the development of insulin resistance, with …

… Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in …
obesity have higher incidence of insulin resistance than those with subcutaneous obesity ( 14 …

… mechanisms by which the enlarged adipose tissue mass that defines obesity causes systemic
insulin resistance … now be referred to as the adipo-insulin axis. There are also grounds for …

… obesity and insulin resistance To investigate the definitive role of TNFa in obesityinduced
insulin resistance, we have generated obese … /+ mice developed marked obesity but the TNFa7/…

… , the insulin resistance associated with the obese state in man appears to be heterogeneous;
some patients display a dose-response relationship consistent with decreased insulin …

… with insulin resistance. Much research has focused on mechanisms that link obesity to insulin
resistance, … Insulin resistance is an important feature of a number of common conditions, …