A MODERN VIEW ON THE PECULIARITIES OF PROTEIN AND LIPID PEROXIDATION IN ADOLESCENT CHILDREN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

Authors

  • Tetiana Pochynok O.O. Bogomolets National Medical University https://orcid.org/0000-0003-0802-2071
  • Maryna Vasiukova O.O. Bogomolets National Medical University

DOI:

https://doi.org/10.30888/2663-5712.2026-35-02-092

Keywords:

children, undifferentiated connective tissue dysplasia, protein peroxidation, lipid peroxidation, antioxidant enzymes, antioxidant defense system.

Abstract

The complexity of the morphology, functions and prevalence of connective tissue in the body determine the active participation of its main elements in the formation and development of many types of pathology. According to research conducted by the Departm

References

Починок Т.В. Окисний стрес та стан систем зсідання крові та фібринолізу у дітей з недиференційованою дисплазією сполучної тканини / Т.В. Починок, А.В. Коцюруба, П.Г. Гриценко та ін.. //Педіатрія, акушерство та гінекологія. 2011. №1 (443). – С. 27-33.

Wulf D. Free radicals in the physiological control of cell function. Physiol Rev. 2002; 82:47-95.

О.В.Колеснікова, А.О.Радченко. Сучасний погляд на механізми розвитку оксидативного стресу і його біомаркери при найбільш поширених неінфекційних захворюваннях // Український терапевтичний журнал.-№1.-2020 DOI: https://doi.org/10.30978/UTJ2020-1-51

Guzik TJ, Mussa S, Gastaldi D, et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus. Circulation. 2002; 105(14): 1656–1662.

Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 1993;91(6): 2546–2551.

Sanguigni S, Pignatelli P, Caccese D, et al. Increased Superoxide anion production by platelets in hypercholesterolemic patients. Thromb Haemost. 2002; 87(5): 796-801.

Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol. 1992; 263(2 Pt 2): H321-H326.

Raij L, DeMaster EG, Jaimes EA. Cigarette smoke-induced endothelium dysfunction: role of superoxide anion. J Hypertens. 2001; 19(5):891-897.

Nedelikovic ZS, Gorce N, Loscalzo J. Mechanisms of oxidative stress and vascular dysfunction. Postgrad Med J. 2003; 79(930):195-199.

Chakravarti B, Chakravarti DN. Oxidative modification of proteins: age-related changes. Gerontology. 2007; 53: 128-139.

Dean RT, Hunt JV, Grant AJ. Free radical damage to proteins: the influence of the relative localization of radical generation, antioxidants and target proteins. Free Rad Biol Med. 1991; 11:161-165.

Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek. 2004; 57(9-10):453-5.

Grotto D, Maria LS, Valentini J. Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification. Quím Nova. 2009; 32(1):169-174.

Beutler E. Glutathion. In: Beutler E (ed) Red Cell Metabolism: A Manual of Biochemical Methods. Grune and Stratton, New York, 1975; 105–107.

Ateş NA, Yildirim O, Tamer L, et al. Plasma catalase activity and malondialdehyde level in patients with cataract. Eye (Lond). 2004; 18(8):785-788.

Fridovich I. Superoxide radical and superoxide dismutases. Acc Chem Res. 1972; 5(10):321–326.

Fındıklı E, Camkurt MA, İzci F, et al. The diagnostic value of malondialdehyde, superoxide dismutase and catalase activity in drug naïve, first episode, non-smoker generalized anxiety disorder patients. Clin Psychopharmacol Neurosci. 2018; 16(1):88-94.

Починок Т.В. Васюкова М.М. Тяжка О.В. Чернишова О.В. Спосіб прогнозування формування дисплазій сполучної тканини та порушень імунітету у дітей. Патент на корисну модель № 15959.-//Офіційний бюлетень «Промислова власність».- 2006.-№7.-с.5.23, від 17.07.2006

Stalnaya ID, Garishvili TG. Method for the determination of malonic dialdehyde using thiobarbituric acid. In: Orekhovich VN, editor. Modern Methods in Biochemistry. M. Medicine. 1977.-p.66

Onopchenko OV, Kosiakova GV, Meged EF, Klimashevsky VM, Hula NM. The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance. Ukr Biochem J. 2014; 86(6):119-128.

Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-254.

Kim HY, Wang TC, Ma YC. Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. Anal Chem. 1994; 66(22):3977-3982.

Починок Т.В., Фік Л.О, Васюкова М.М., Мельничук В.В., Чернишова О.В. Перекисне окислення ліпідів у дітей з недиференційованою дисплазією сполучної тканини // Педіатрія, акушерство та гінекологія. – 2011.- №4.- С.27-33.

Schumann-Gillett A, O'Mara ML. The effects of oxidised phospholipids and cholesterol on the biophysical properties of POPC bilayers. Biochim Biophys Acta Biomembr. 2019; 1861(1):210-219.

Solís-Calero C, Ortega-Castro J, Frau J, Muñoz F. Nonenzymatic reactions above phospholipid surfaces of biological membranes: reactivity of phospholipids and their oxidation derivatives. Oxid Med Cell Longev. 2015; 319505.

Kessel A, Ben-Tal N, May S. Interactions of cholesterol with lipid bilayers: the preferred configuration and fluctuations. Biophys J. 2001; 81(2): 643–668.

Raffy S, Teissié J. Control of lipid membrane stability by cholesterol content. Biophys J. 1999; 76(4):2072-2080.

Published

2026-01-30

How to Cite

Починок, Т., & Васюкова, М. (2026). A MODERN VIEW ON THE PECULIARITIES OF PROTEIN AND LIPID PEROXIDATION IN ADOLESCENT CHILDREN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA. SWorldJournal, 2(35-02), 257–270. https://doi.org/10.30888/2663-5712.2026-35-02-092

Issue

Section

Articles