Have been considered the role of macro-and microelements-Ca, Mg, Zn, Fe, and Cu imbalance in the blood serum and pancreatic tissue homogenate of rats, whose pregnancy took place against the background of chronic immobilization stress and their newborn offspring, compared to the control, where it is established: heterogeneity changes in the level of macro-and microelement composition as a whole, can be traced regularity in the direction of deviations from the control values of indicators in the tissue of the pancreas, which consists in a decrease in the level of Ca and Mg and Zn and Cu in female rats and their offspring. A more stable reduction of Zn and Cu is determined in the blood serum of female rats and their newborn offspring. Changes in macro-and microelement composition in pancreatic tissue and blood serum are not identical, which manifests organ specificity regarding their balance in different organs, particularly in the pancreas. Such changes in the composition of macro-and microelements with a predominant deficiency of Ca, Mg, Zn, and Cu are an essential link in the pathogenesis of pancreatic damage, which occurs during stereotypic events inherent in the body's neurohumoral response to stress as a result of animal immobilization.