Nonsteroidal anti-inflammatory drugs have a wide spectrum of therapeutic action, uniquely combining anti-inflammatory, analgesic, antipyretic and antithrombotic effects, influencing the processes of neogenesis, cell adhesion and apoptosis. That is why NSAIDs are the most widely used drugs in medicine. Every year, 500 million prescriptions for these drugs are written in the world, about 30 million people take them every day, 2/3 of patients without a prescription and medical supervision. NSAID-induced gastroduodenopathy develops when NSAIDs are taken at a dose that inhibits prostaglandin production and increases gastric motility, caus-ing increased mucosal permeability, neutrophil infiltration, and free radical formation, which ultimately leads to gastric damage.