The molecular biology of chronic myeloid leukemia

MWN Deininger, JM Goldman… - Blood, The Journal of the …, 2000 - ashpublications.org
… eliminated or that an immune response suppresses or eliminates … feature of chronic
myeloproliferative disorders. Several other reciprocal translocations have been cloned from patients

[HTML][HTML] Regulation of hematopoietic and leukemic stem cells by the immune system

C Riether, CM Schürch, AF Ochsenbein - Cell death & differentiation, 2015 - nature.com
… Since the first description of leukemic stem cells (LSCs), our … chronic myeloid leukemia
(CML) and in some forms of acute … differentiated, heterogenic leukemic blasts that feature a high …

[HTML][HTML] Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia

M Ilander, U Olsson-Strömberg, H Schlums, J Guilhot… - Leukemia, 2017 - nature.com
… (c) Clinical characteristics of patients according to their TKI … the immune system is able to
keep the remaining leukemicstate seem to hold for a while, but gradually the leukemic cells …

Gene expression changes associated with progression and response in chronic myeloid leukemia

JP Radich, H Dai, M Mao, V Oehler… - Proceedings of the …, 2006 - National Acad Sciences
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease with distinct biological
and clinical features… of genes involved in inflammatory and immune response. In addition, …

Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring

E Jabbour, H Kantarjian - American journal of hematology, 2018 - Wiley Online Library
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm … 15% of newly diagnosed
cases of leukemia in adults. … for patients with good performance status and organ functions, …

Chronic myeloid leukemia: diagnosis and treatment

A Quintás-Cardama, JE Cortes - Mayo Clinic Proceedings, 2006 - Elsevier
… that patients with CML-CP have a competent immune system … Among the 5% to 10% of
patients with CML clinical features … The characteristics and management of atypical CML are not …

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

F McClanahan, B Hanna, S Miller… - Blood, The Journal …, 2015 - ashpublications.org
… by a reactivation of immune effector functions. This included … -L1 blockade reverses
CLL-induced skewing of myeloid cells … Our current understanding of the immune system in CLL

… blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts

R Le Dieu, DC Taussig, AG Ramsay… - Blood, The Journal …, 2009 - ashpublications.org
… The patient characteristics are shown in Table 1. Frozen PB mononuclear … immune response
is impaired. In conclusion, our findings improve our understanding of the immune response

An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

A Lasry, B Nadorp, M Fornerod, D Nicolet, H Wu… - Nature cancer, 2023 - nature.com
immune system is activated, our findings suggest that in a subset of patients, inflammation
triggers an ineffective response … We investigated the molecular characteristics and outcome …

Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency'hematopoiesis

AD Panopoulos, SS Watowich - Cytokine, 2008 - Elsevier
… This serves to control the immediate host immune response and attract other cells, such as
… We found that these functions of STAT3 were independent of SOCS3, as mice with myeloid-…